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SET7/9 (human recombinant)

Cayman Chemical Item Number 10320

KMT7; SETD7/9; SET Domain-containing Protein 7/9

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Description

Source: active recombinant N-terminal His-tagged SET7/9 amino acids 1-366, purified from E. coli · Mr: 43.3 kDa · Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function.1 Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase.2 SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10.3 Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation.1 SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.

1 Kurash, J.K., Lei, H., Shen, Q., et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell 29 392-400 (2008).

2 Xiao, B., Jing, C., Wilson, J.R., et al. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature 421 652-656 (2003).

3 Couture, J., Collazo, E., Hauk, G., et al. Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol 13(2) 140-146 (2006).

Synonyms
  • KMT7
  • SETD7/9
  • SET Domain-containing Protein 7/9
Formulation 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol
Purity ≥95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Kurash, J.K., Lei, H., Shen, Q., et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell 29 392-400 (2008).

Xiao, B., Jing, C., Wilson, J.R., et al. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature 421 652-656 (2003).

Couture, J., Collazo, E., Hauk, G., et al. Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol 13(2) 140-146 (2006).
Size Price Quantity Subtotal
25 µg $92.00 $0.00
50 µg $175.00 $0.00
100 µg $331.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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