Cayman Chemical | Chemokine-Like Receptor 1 Polyclonal Antibody | Description • GPCR ChemR23; Resolvin E1 Receptor; ChemerinR; DEZ; CMKLR1; ChemR23

10325 Chemokine-Like Receptor 1 Polyclonal Antibody

GPCR ChemR23; Resolvin E1 Receptor; ChemerinR; DEZ; CMKLR1; ChemR23

• See more Immunocytochemistry; Western Blot; Antibodies; Atherosclerosis; Endocrinology; Immunology; Infectious Disease; Inflammation; Nutrition/Diet; Obesity; Vascular Disease

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Antigen: human CMKLR1 amino acids 358–371 (NERTSMNERETGML) · Host: rabbit · Application(s): WB, FC, and IHC · Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages.¹ This receptor is also expressed in brain, liver, lung, and kidney tissues.^1,2 Chemerin, or TIG2, has been identified as the natural ligand for this receptor.³ Resolvin E1 has also been identified as a ligand for CMKLR1; acting to dampen cellular responses to inflammation.^1,4,5 Chemerin is an 18 kDa protein that plays a role in immunity, inflammation, chemotaxis, and has been identified as an adipokine.^6,7,8 Human CMKLR1 shares 80% sequence homology with its murine ortholog.³ The human receptor exists in two isoforms, differing only by two amino acids due to a premature stop codon. Isoform one has 363 amino acids and an expected molecular weight of 42.3 kDa. Cayman’s CMKLR1 polyclonal antibody recognizes the C-terminal region of the protein and cell permeabilization is recommended prior to whole cell staining.

1 Arita, M., Bianchini, F., Aliberti, J., et al. Sterochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 201(5) 713-722 (2005).

2 Takahashi, M., Takahashi, Y., Takahashi, K., et al. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett 582 573-578 (2008).

3 Wittamer, V., Grégoire, F., Robberecht, P., et al. The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. The Journal of Biological Chemistry 279(11) 9956-9962 (2004).

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6 Roh, S., Song, S., Choi, K., et al. Chemerin-a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun 362 1013-1018 (2007).

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Pricing updated 2010-03-16.
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