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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Cystathionine γ-Lyase (human recombinant)

Cayman Chemical Item Number 10329

CTH; Cystathionase; CGL

Cystathionine γ-Lyase (human recombinant)

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Description

Source: Recombinant protein expressed in E. coli · Mr: 44.5 kDa · Transsulfuration and reverse transsulfuration comprise part of the metabolic interconversion of the sulfur-containing amino acids cysteine and methionine.1 Reverse transsulfuration is catalyzed by the enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CGL) in fungi and mammals.1 Specifically, CGL catalyzes the conversion of cystathionine to cysteine in a pyridoxal-5'-phosphate-dependant reaction.2 At elevated levels, homocysteine is an independent risk factor for cardiovascular diseases and other complex disorders.2 The mammalian transsulfuration pathway is one of two major metabolic routes for homocysteine removal. Besides homocysteine removal, transsulfuration contributes significantly to the intracellular cysteine pool.2 Cysteine is used for biosynthesis of glutathione, and is also the primary substrate for H2S biosynthesis. CGL is one of two major enzymes that catalyzes the formation of H2S from cysteine. 2 H2S generation is a biological gasotransmitter, a neuromodulator, a vasodilator, and plays an important role in inflammation.2

1 Steegborn, C., Clausen, T., Sondermann, P., et al. Kinetics and inhibition of recombinant human cystathionine γ-lyase. Toward the rational control of transsulfuration. J Biol Chem 274(18) 12675-12684 (1999).

2 Zhu, W., Lin, A., and Banerjee, R. Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine γ-lyase. Biochemistry 47 6226-6232 (2008).

Synonyms
  • CTH
  • Cystathionase
  • CGL
Formulation 70 mM Tris, pH 8.1, containing 150 mM sodium chloride, 20% glycerol, and 10 µM pyridoxal-5’-phosphate
Purity ≥85%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere

Background Reading

Zhu, W., Lin, A., and Banerjee, R. Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine γ-lyase. Biochemistry 47 6226-6232 (2008).

Steegborn, C., Clausen, T., Sondermann, P., et al. Kinetics and inhibition of recombinant human cystathionine γ-lyase. Toward the rational control of transsulfuration. J Biol Chem 274(18) 12675-12684 (1999).
Size Price Quantity Subtotal
25 µg $99.00 $0.00
50 µg $188.00 $0.00
100 µg $356.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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