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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

(R)-AM1241 Exclusive

Cayman Chemical Item Number 10491

(+)-AM1241 (CAS 444912-51-0)

(R)-AM1241 (CAS 444912-51-0)

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Description

(R)-AM1241 avidly binds the peripheral cannabinoid receptor (CB2) (Ki = 15 nM) with over 100-fold selectivity over central cannabinoid receptor (CB1).1 Like the racemate AM1241 (Item No. 10010118), (R)-AM1241 is an agonist of human CB2, but an inverse agonist of rat and mouse CB2. In rats, (R)-AM1241 produces antinociception to thermal, but not mechanical, pain.2 The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528, but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone.2

1 Bingham, B., Jones, P.G., Uveges, A.J., et al. Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers. Br J Pharmacol 151 1061-1070 (2007).

2 Rahn, E.J., Zvonok, A.M., Makriyannis, A., et al. Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: Lack of dependence upon opioid receptor activation. AAPS J 12(2) 147-157 (2010).

Synonyms
  • (+)-AM1241
Formal Name (2-​iodo-​5-​nitrophenyl)[1-​[[(2R)-​1-​methyl-​2-​piperidinyl]methyl]-​1H-​indol-​3-​yl]methanone
CAS Number 444912-51-0
Molecular Formula C22H22INO3
Formula Weight 503.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(C1=CC([N+]​([O-]​)​=O)​=CC=C1I)​C2=CN(C[C@H]​3CCCCN3C)​C4=CC=CC=C42

Background Reading

Bingham, B., Jones, P.G., Uveges, A.J., et al. Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers. Br J Pharmacol 151 1061-1070 (2007).

Rahn, E.J., Zvonok, A.M., Makriyannis, A., et al. Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: Lack of dependence upon opioid receptor activation. AAPS J 12(2) 147-157 (2010).

Rahn, E.J., Zvonok, A.M., Thakur, G.A., et al. Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. J Pharmacol Exp Ther 327(2) 584-591 (2008).
Size Price Quantity Subtotal
1 mg $50.00 $0.00
5 mg $225.00 $0.00
10 mg $400.00 $0.00
25 mg $875.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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