4-pentynoyl-Coenzyme A (trifluoroacetate salt)

4-pentynoyl-Coenzyme A (trifluoroacetate salt) Exclusive

Cayman Chemical Item Number 10547

Click Tag™ 4-pentynoyl-CoA

Description

Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins both in vivo and in vitro.¹ As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine methyl transferases. An azide-alkyne bioconjugation reaction, known as ‘click chemistry’, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.²

1 Yang, Y., Ascano, J.M., and Hang, H.C. Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc 132 3640-3641 (2010).

2 Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov Today 8(24) 1128-1137 (2003).

Synonyms

Click Tag™ 4-pentynoyl-CoA

Formal Name

S-4-pentynoate coenzyme A, trifluoroacetate salt

Molecular Formula

C₂₆H₄₀N₇O₁₇P₃S · C₂HF₃O₂

Formula Weight

961.6

Formulation

A lyophilized powder

Purity

≥95%

Stability

2 years

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

SMILES

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[O-]C(C(F)(F)F)=O.[NH3+]C1=NC=NC2=C1N=CN2[C@@]3([H])[C@@](O)([H])[C@@](OP(O)(O)=O)([H])[C@](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC#C)=O)=O)=O)(O)=O)(O)=O)([H])O3

Background Reading

Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov Today 8(24) 1128-1137 (2003).

Yang, Y., Ascano, J.M., and Hang, H.C. Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc 132 3640-3641 (2010).

Size

Price

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Subtotal

500 µg 
$60.00

$0.00

1 mg 
$114.00

$0.00

5 mg 
$480.00

$0.00

10 mg 
$840.00

$0.00

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4-pentynoyl-Coenzyme A (trifluoroacetate salt) Exclusive