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JWH 200

Cayman Chemical Item Number 10902

(CAS 103610-04-4)

JWH 200 (CAS 103610-04-4)

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Description

JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor ligand. It binds to the CB1 receptor with high-affinity (IC50 = 7.8-42 nM).1,2 The effects of JWH 200 in locomotor activity, tail-flick latency, hypothermia, and ring-immobility tests are comparable or superior to Δ9-THC or WIN-55,212.3 It potently inhibits the contraction of electrically-stimulated murine vas deferens (IC50 = 3.7-6.0 nM).4,5

1 Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J Med Chem 38 3094-3105 (1995).

2 Huffman, J.W., Mabon, R., Wu, M., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorg Med Chem 11 539-549 (2003).

3 Compton, D.R., Gold, L.H., Ward, S.J., et al. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from D9-tetrahydrocannabinol. J Pharmacol Exp Ther 263(3) 1118-1126 (1992).

4 Pacheco, M., Childers, S.R., Arnold, R., et al. Aminoalkylindoles: Actions on specific G-protein-linked receptors. J Pharmacol Exp Ther 257(1) 170-183 (1991).

5 Bell, M.R., D'Ambra, T.E., Kumar, V., et al. Antinociceptive (aminoalkyl) indoles. J Med Chem 34 1099-1110 (1991).

Formal Name [1-​[2-​(4-​morpholinyl)ethyl]-​1H-​indol-​3-​yl]-​1-​naphthalenyl-​methanone
CAS Number 103610-04-4
Molecular Formula C25H24N2O2
Formula Weight 384.5
Formulation A crystalline solid
Purity ≥98%
λmax 219, 314 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C(c1cn(CCN2CCOCC2)​c2ccccc12)​c1cccc2ccccc12
Size Price Quantity Subtotal
5 mg $56.00 $0.00
10 mg $106.00 $0.00
25 mg $252.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

This product requires special processing and/or additional information before it can be shipped. A Customer Service representative will contact you within 24 hours of receipt of your order.

Warning This product is not for human or veterinary use.

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