Phenylpiperazine is the base compound from which a broad series of bioactive products are derived. Many are entactogenic drugs which induce central serotonin release.1,2,3 Substituted phenylpiperazines, such as 1-(3-chlorophenyl)piperazine, have been identified as designer drugs or drugs of abuse.4,5 This product is intended for forensic applications.
1
Eriksson, E., Engberg, G., Bing, O., et al. Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain. Neuropsychopharmacology 20(3) 287-296 (1999).
2
Baumann, M.H., Clark, R.D., Budzynski, A.G., et al. N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or “Ecstasy”). Neuropsychopharmacology 30 550-560 (2005).
3
Hill, S.L., and Thomas, S.H. Clinical toxicology of newer recreational drugs. Clin Toxicol (Phila) 49 705-719 (2011).
4
Nagai, F., Nonaka, R., and Satoh Hisashi Kamimura, K. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. Eur J Pharmacol 559(2-3) 132-137 (2007).
5
Arbo, M.D., Bastos, M.L., and Carmo, H.F. Piperazine compounds as drugs of abuse. Drug Alcohol Depend 1-12 (2011).