See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Prostaglandin B2

Cayman Chemical Item Number 11210

PGB2 (CAS 13367-85-6)

Prostaglandin B2 (CAS 13367-85-6)

See more

Description

PGB2 is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 µg/kg).1

1 Liu, F., Orr, J.A., and Wu, J. Prostaglandin B2-induced pulmonary hypertension is mediated by TXA2/PGH2 receptor stimulation. J Am Physiol Soc 1040 L602-L607 (1994).

Synonyms
  • PGB2
Formal Name 9-​oxo-​15S-​hydroxy-​prosta-​5Z,​8(12),​13E-​trien-​1-​oic acid
CAS Number 13367-85-6
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in methyl acetate
Purity ≥98%
λmax 278 nm
ε 26
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C1C(C/C=C\CCCC(O)​=O)​=C(/C=C/[C@@H]​(O)​CCCCC)​CC1

Background Reading

Hamberg, M., and Samuelsson, B. Prostaglandins in human seminal plasma. J Biol Chem 241 257-263 (1966).

Liu, F., Orr, J.A., and Wu, J. Prostaglandin B2-induced pulmonary hypertension is mediated by TXA2/PGH2 receptor stimulation. J Am Physiol Soc 1040 L602-L607 (1994).

Borgeat, P., Picard, S., Vallerand, P., et al. Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography. Methods Enzymol 187 98-116 (1990).

Antoine, C., Murphy, R.C., Henson, P.M., et al. Time-dependent utilization of platelet arachidonic acid by the neutrophil in formation of 5-lipoxygenase products in platelet-neutrophil co-incubations. Biochim Biophys Acta 1128 139-146 (1992).

Wickramasinghe, J.A.F., and Shaw, S.R. Separation of prostaglandins A, B and C by thin-layer chromatography on ferric chloride impregnated silica gel. Prostaglandins 4 903-913 (1973).

Show all 5 Hide all but first 3

Prostaglandin B2 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $22.00 $0.00
5 mg $99.00 $0.00
10 mg $176.00 $0.00
25 mg $385.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

19(R)-hydroxy Prostaglandin B2
Carbocyclic Thromboxane A2
Pinane Thromboxane A2
Prostaglandin A2
Prostaglandin B2-d4
Prostaglandin B2 Quant-PAK
Prostaglandin E2
Prostaglandin H2
Show all 8 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?