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Cytochalasin B New

Cayman Chemical Item Number 11328

Phomin; NSC 107658 (CAS 14930-96-2)

Cytochalasin B (CAS 14930-96-2)

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Description

Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments.1 By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.2,3,4 Cytochalasin B is broadly used in cytological studies involving any of these many processes that depend on actin polymerization.5,6,7

1 Theodoropoulos, P.A., Gravanis, A., Tsapara, A., et al. Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem Pharmacol 47(10) 1875-1881 (1994).

2 Steinberg, M.S., and Wiseman, L.L. Do morphogenetic tissue rearrangements require active cell movements? The reversible inhibition of cell sorting and tissue spreading by cytochalasin B. J Cell Biol 55 606-615 (1972).

3 Spudich, J.A., and Lin, S. Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement/microfilaments/rabbit striated muscle). Proc Nat Acad Sci USA 69(2) 442-446 (1972).

4 Estensen, R.D., and Plagemann, P.G.W. Cytochalasin B: Inhibition of glucose and glucosamine transport. Proc Nat Acad Sci USA 69(6) 1430-1434 (1972).

5 Snezhko, A., Barlan, K., Aranson, I.S., et al. Statistics of active transport in Xenopus melanophores cells. Biophys J 99 3216-3223 (2010).

6 Yu, Y., Dumollard, R., Rossbach, A., et al. Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation. J Cell Physiol 224(3) 672-680 (2010).

7 Yu, Y., Maguire, T.G., and Alwine, J.C. Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection. J Virol 85(4) 1573-1580 (2011).

Synonyms
  • Phomin
  • NSC 107658
Formal Name (3E,​5R,​9R,​11E,​12aS,​13S,​15S,​15aS,​16S,​18aS)-​6,​7,​8,​9,​10,​12a,​13,​14,​15,​15a,​16,​17-​dodecahydro-​5,​13-​dihydroxy-​9,​15-​dimethyl-​14-​methylene-​2H-​oxacyclotetradecino[2,​3-​d]isoindole-​2,​18(5H)-​dione
CAS Number 14930-96-2
Molecular Formula C29H37NO5
Formula Weight 479.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1/C=C/[C@H]​(O)​CCC[C@@H]​(C)​C/C=C/[C@]​([C@H]​(O)​C([C@@H]​(C)​[C@@]​2([H]​)​[C@H]​(CC3=CC=CC=C3)​NC4=O)​=C)​([H]​)​[C@@]​24O1
Size Price Quantity Subtotal
1 mg $35.00 $0.00
5 mg $90.00 $0.00
10 mg $162.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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