Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday.
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Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.
Cytochalasin B is a cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments.1 By disrupting actin polymerization, cytochalasin B blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.2,3,4 Cytochalasin B is broadly used in cytological studies involving any of these many processes that depend on actin polymerization.5,6,7
1
Theodoropoulos, P.A., Gravanis, A., Tsapara, A., et al. Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem Pharmacol47(10)1875-1881(1994).
2
Steinberg, M.S., and Wiseman, L.L. Do morphogenetic tissue rearrangements require active cell movements? The reversible inhibition of cell sorting and tissue spreading by cytochalasin B. J Cell Biol55606-615(1972).
3
Spudich, J.A., and Lin, S. Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement/microfilaments/rabbit striated muscle). Proc Nat Acad Sci USA69(2)442-446(1972).
4
Estensen, R.D., and Plagemann, P.G.W. Cytochalasin B: Inhibition of glucose and glucosamine transport. Proc Nat Acad Sci USA69(6)1430-1434(1972).
5
Snezhko, A., Barlan, K., Aranson, I.S., et al. Statistics of active transport in Xenopus melanophores cells. Biophys J993216-3223(2010).
6
Yu, Y., Dumollard, R., Rossbach, A., et al. Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation. J Cell Physiol224(3)672-680(2010).
7
Yu, Y., Maguire, T.G., and Alwine, J.C. Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection. J Virol85(4)1573-1580(2011).