Thiolutin • Acetopyrrothin; NSC 3927 (CAS 87-11-6) || Cayman Chemical

Thiolutin New

Cayman Chemical Item Number 11350

Acetopyrrothin; NSC 3927 (CAS 87-11-6)

Thiolutin (CAS 87-11-6)

Description

Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC₅₀ = 3 μg/ml).^1,2,3 Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC₅₀ < 1 μM) and S180 tumor-induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal elements.^4,5

1 Jimenez, A., Tipper, D.J., and Davies, J. Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob Agents Chemother 3(6) 729-738 (1973).

2 Tipper, D.J. Inhibition of yeast ribonucleic acid polymerases by thiolutin. J Bacteriol 116(1) 245-256 (1973).

3 Khachatourians, G.G., and Tipper, D.J. Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutin. J Bacteriol 119(3) 795-804 (1974).

4 Dai, S., Jia, Y., Wu, S., et al. Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin. J Proteome Res 7(10) 4384-4395 (2008).

5 Jia, Y., Wu, S., Isenberg, J.S., et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones 15 165-181 (2010).

Synonyms

Acetopyrrothin
NSC 3927

Formal Name

N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-acetamide

CAS Number

87-11-6

Molecular Formula

C₈H₈N₂O₂S₂

Formula Weight

228.3

Formulation

A crystalline solid

Purity

≥97%

λ_max

310, 390 nm

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

SMILES

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CC(NC1=C2C(N(C)C1=O)=CSS2)=O

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1 mg 
$58.00

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5 mg 
$171.00

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10 mg 
$304.00

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Thiolutin (CAS 87-11-6)

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