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Diacetoxyscirpenol New

Cayman Chemical Item Number 11427

Scirpenetriol 4,15-diacetate; NSC 141537; Anguidin; NSC 177378; DAS (CAS 2270-40-8)

Diacetoxyscirpenol (CAS 2270-40-8)

Description

Diacetoxyscirpenol (DAS) is a potent, trichothecene mycotoxin produced by certain Fusarium strains, which play an important role as plant pathogens, causing a wide range of diseases.1 It is toxic to fungi, plants, animals, and various mammalian cell cultures, inhibiting de novo protein synthesis.2 In a biological activity assay, DAS was shown to inhibit expression of the Arabidopsis MAMP-responsive reporter gene WRKY29p::GUS with an IC50 value of 50 nM, thereby suppressing a rapid cell death immune response important for plant defense.3

1 Bauer, J., Bollwahn, W., Gareis, M., et al. Kinetic profiles of diacetoxyscirpenol and two of its metabolites in blood serum of pigs. Appl Environ Microbiol 49(4) 842-845 (1985).

2 Shams, M., Mitterbauer, R., Corradini, R., et al. Isolation and characterization of a new less-toxic derivative of the Fusarium mycotoxin diacetoxyscirpenol after thermal treatment. J Agric Food Chem 59 9709-9714 (2011).

3 Serrano, M., Hubert, D.A., Dangl, J.L., et al. A chemical screen for suppressors of the avrRpm1-RPM1-dependent hypersensitive cell death response in Arabidopsis thaliana. Planta 231 1013-1023 (2010).

Synonyms
  • Scirpenetriol 4,15-diacetate
  • NSC 141537
  • Anguidin
  • NSC 177378
  • DAS
Formal Name (3α,​4β)-​12,​13-​epoxy-​4,​15-​diacetate-​trichothec-​9-​ene-​3,​4,​15-​triol
CAS Number 2270-40-8
Molecular Formula C19H26O7
Formula Weight 366.4
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC1=C[C@]​2([H]​)​[C@]​([C@]​([C@H]​(OC(C)​=O)​[C@H]​3O)​(C)​[C@@]​4(OC4)​[C@]​3([H]​)​O2)​(COC(C)​=O)​CC1
Size Price Quantity Subtotal
1 mg $49.00 $0.00
5 mg $122.00 $0.00
10 mg $216.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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