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Prostaglandin Bx Exclusive

Cayman Chemical Item Number 11510

PGBx (CAS 39306-29-1)

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Description

PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2

1 Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitochondria by a stable free-radical prostaglandin polymer (PGBχ). Proc Natl Acad Sci USA 76 1598-1602 (1979).

2 Kumashiro, R., Devlin, T.M., Kholoussy, A.M., et al. Prostaglandin Bχ in the prevention of stress ulcers in rats. Int Surg 70 247-250 (1985).

3 Franson, R.C., Rosenthal, M.D., and Regelson, W. Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity. Prostaglandins Leukot Essent Fatty Acids 43 63-70 (1991).

Synonyms
  • PGBx
CAS Number 39306-29-1
Molecular Formula (PGB)n n=3-5
Formula Weight 1.0
Formulation A solution in ethanol
Purity Mixture of oligomers
λmax 236 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Kumashiro, R., Devlin, T.M., Kholoussy, A.M., et al. Prostaglandin Bχ in the prevention of stress ulcers in rats. Int Surg 70 247-250 (1985).

Franson, R.C., Rosenthal, M.D., and Regelson, W. Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity. Prostaglandins Leukot Essent Fatty Acids 43 63-70 (1991).

Hidaka, S., Norikazu, M., Ohnishi, S.T., et al. Inhibitory effect of prostaglandin oligomer derivatives on 9,10-dimethyl-1,2-benzanthracene-induced lingual carcinomas. Cancer Lett 61 171-176 (1992).

Ohnishi, S.T., and Devlin, T.M. Calcium ionophore activity of a prostaglandin B1 derivative (PGBχ). Biochem Biophys Res Commun 89 240-245 (1979).

Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitochondria by a stable free-radical prostaglandin polymer (PGBχ). Proc Natl Acad Sci USA 76 1598-1602 (1979).

Ohnishi, S.T., Barr, J.K., Katagi, C., et al. Protection of rat spinal cord against contusion injury by new prostaglandin derivatives. Arzneimittelforschung 39 236-239 (1989).

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Size Price Quantity Subtotal
500 µg $24.00 $0.00
1 mg $46.00 $0.00
5 mg $192.00 $0.00
10 mg $336.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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