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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
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Prostaglandin B3 Exclusive

Cayman Chemical Item Number 11990

PGB3 (CAS 36614-32-1)

Prostaglandin B3 (CAS 36614-32-1)

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Description

Prostaglandin B3 (PGB3) is a non-enzymatic dehydration product resulting from the treatment of Prostaglandin E3 (PGE3) with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARγ, PGB3 exhibited a Ki value greater than 1 mM.1 In contrast, PGB1 and PGB2 showed significantly higher affinity for PPARγ, with Ki values of 26 and 77 µM, respectively, the same assay.

1 Ferry, G., Bruneau, V., Beauverger, P., et al. Binding of prostaglandins to human PPARγ: Tool assessment and new natural ligands. Eur J Pharmacol 417 77-89 (2001).

Synonyms
  • PGB3
Formal Name 9-​oxo-​15S-​hydroxy-​prosta-​5Z,​8(12),​13E,​17Z-​tetraen-​1-​oic acid
CAS Number 36614-32-1
Molecular Formula C20H28O4
Formula Weight 332.4
Formulation A solution in methyl acetate
Purity >97%
λmax 280 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1C(C/C=C\CCCC(O)​=O)​=C(/C=C/[C@@H]​(O)​C/C=C\CC)​CC1

Background Reading

Ferry, G., Bruneau, V., Beauverger, P., et al. Binding of prostaglandins to human PPARγ: Tool assessment and new natural ligands. Eur J Pharmacol 417 77-89 (2001).

Prostaglandin B3 is available in the following screening library:

Size Price Quantity Subtotal
50 µg $85.00 $0.00
100 µg $162.00 $0.00
500 µg $680.00 $0.00
1 mg $1,190.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Prostaglandin E3 Exclusive

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