Prostaglandin D1(PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl. There are no known reports of its biological activity. PGD1 is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2.1
1
Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem26790-799(1983).
Synonyms
PGD1 Alcohol
Formal Name
1,9α,15S-trihydroxy-prost-13E-en-11-one
CAS Number
1176470-37-3
Molecular Formula
C20H36O4
Formula Weight
340.5
Formulation
A crystalline solid
Purity
>99%
Stability
1 year
Storage
-20°C
Shipping
Wet ice
in continental US; may vary elsewhere
SMILES
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CCCCCC(O)/C=C/[C@H]1C(=O)CC(O)C1CCCCCCCO
Background Reading
Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem26790-799(1983).
Prostaglandin D1 Alcohol is available in the following screening
libraries: