Cayman Chemical | Prostaglandin D2 | Description • PGD2 (CAS 41598-07-6)

12010 Prostaglandin D₂

PGD₂ (CAS 41598-07-6)

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• See more Eicosanoids; Prostaglandins; Allergy/Asthma; Cancer; Neuroscience

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PGD₂ is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.¹ Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes.¹ PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.^2,3 In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature.^2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.⁴ PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ of 6.8 µM.⁵

1 Roberts, L.J., Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D₂ in a human female with mastocytosis. Prostaglandins 30 383-400 (1985).

2 Hayaishi, O. Sleep-wake regulation by prostaglandins D₂ and E₂. J Biol Chem 263 14593-14596 (1988).

3 Onoe, H., Ueno, R., Fujita, I., et al. Prostaglandin D₂, a cerebral sleep-inducing substance in monkeys. Proc Natl Acad Sci USA 85 4082-4086 (1988).

4 Giles, H., Leff, P. The biology and pharmacology of PGD₂. Prostaglandins 35 277-300 (1988).

5 Kikuchi, Y., Kita, T., Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metast Rev 13 309-315 (1994).

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Pricing updated 2010-03-18.
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