Cayman Chemical | BLT1 Receptor Monoclonal Antibody | Description • Leukotriene B4 Receptor 1; LTB4 Receptor 1; BLTR1

120111 BLT₁ Receptor Monoclonal Antibody

Leukotriene B₄ Receptor 1; LTB₄ Receptor 1; BLTR1

• See more Flow Cytometry; Immunocytochemistry; Immunohistochemistry; Molecular Biology; Receptor Biochemistry; Antibodies; Leukotrienes; Immunology

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Antigen: HeLa cells transfected with human BLT₁ · Host: mouse, clone 7B1 · Application(s): ICC, IHC of frozen sections, and flow cytometry · The human BLT₁ receptor is a G protein-coupled receptor that mediates the proinflammatory effects of leukotriene B₄ (LTB₄).¹ Northern blotting reveals that the BLT₁ receptor is highly expressed in leukocytes, U937 cells, and to a much lower extent in spleen and thymus.¹ Sheep lung membranes have also been identified as a rich source for receptor isolation and purification.² A second, low-affinity LTB₄ receptor, BLT₂, has also been cloned and characterized.^3,4,5 Cayman Chemical’s BLT₁ Receptor Monoclonal Antibody is a useful tool for the detection of human BLT₁ by flow cytometry, immunohistochemistry, and immunocytochemistry. The antibody does not cross react with the other leukotriene receptors (BLT₂, CysLT₁, or CysLT₂) and does not work for Western blot analysis of BLT₁.

1 Yokomizo, T., Izumi, T., Chang, K., et al. A G-protein-coupled receptor for leukotriene B₄ that mediates chemotaxis. Nature 387 620-624 (1997).

2 Votta, B., Keefer, J., Mong, S. Characterization of the soluble leukotriene B₄ receptor from sheep lung membranes. Biochem J 270 213-218 (1990).

3 Yokomizo, T., Kato, K., Terawaki, K., et al. A second leukotriene B₄ receptor, BLT₂: A new therapeutic target in inflammation and immunological disorders. J Exp Med 193 421-431 (2000).

4 Kamohara, M., Takasaki, J., Matsumoto, M., et al. Molecular cloning and characterization of another leukotriene B₄ receptor. J Biol Chem 275 27000-27004 (2000).

5 Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B₄ receptor. J Biol Chem 275 40686-40694 (2000).

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Pricing updated 2010-02-09.
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