Cayman Chemical | BLT2 Receptor Polyclonal Antibody | Description • Leukotriene B4 Receptor 2; LTB4 Receptor 2; BLTR2

120124 BLT₂ Receptor Polyclonal Antibody

Leukotriene B₄ Receptor 2; LTB₄ Receptor 2; BLTR2

• See more Molecular Biology; Receptor Biochemistry; Western Blot; Antibodies; Leukotrienes; Atherosclerosis; Immunology

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Antigen: human BLT₂ receptor amino acids 325-338 (MELRTTPQLKVVGQ) · Host: rabbit · Application(s): WB (recommended primarily for transfected cells) · Leukotriene B₄ (LTB₄) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis. Two G-protein coupled receptors, BLT₁ and BLT₂, which mediate the actions of LTB₄ have been cloned and characterized.^1,2,3,4 The BLT₁ receptor is expressed in leukocytes, U937 cells, and to a much lower extent in spleen and thymus.⁴ The human BLT₂ receptor is a 358 amino acid protein with approximately 40% homology to BLT₁ at the amino acid level.^1,2,3 The BLT₂ receptor is more broadly expressed than the BLT₁ receptor, with highest levels observed in liver, spleen, ovary, intestine, and peripheral blood leukocytes.^1,2,3 Activation of the BLT₂ receptor by LTB₄ leads to Ca2+ mobilization as well as decreases in cyclic AMP, indicating interaction of the receptor with G_q and Gi classes of G-proteins.²

1 Yokomizo, T., Kato, K., Terawaki, K., et al. A second leukotriene B₄ receptor, BLT₂: A new therapeutic target in inflammation and immunological disorders. J Exp Med 193 421-431 (2000).

2 Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B₄ receptor. J Biol Chem 275 40686-40694 (2000).

3 Kamohara, M., Takasaki, J., Matsumoto, M., et al. Molecular cloning and characterization of another leukotriene B₄ receptor. J Biol Chem 275 27000-27004 (2000).

4 Yokomizo, T., Izumi, T., Chang, K., et al. A G-protein-coupled receptor for leukotriene B₄ that mediates chemotaxis. Nature 387 620-624 (1997).

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Pricing updated 2010-03-11.
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