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BW 245C

Cayman Chemical Item Number 12050

(CAS 72814-32-5)

BW 245C (CAS 72814-32-5)

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Description

BW 245C is a selective agonist for the DP1 receptor.1,2 The Ki of BW 245C for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM.1 It has a reported IC50 of 2.5 nM for the inhibition of ADP-induced human platelet aggregation3 and an IC50 of 250 nM for the inhibition of rat platelet aggregation.2

1 Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270 18910-18916 (1995).

2 Town, M., Casals-Stenzel, J., and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. Prostaglandins 25 13-28 (1983).

3 Narumiya, S., and Toda, N. Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. Br J Pharmacol 85 367-375 (1985).

Formal Name (4S)-​(3-​[(3R,​S)-​3-​cyclohexyl-​3-​hydroxypropyl]-​2,​5-​dioxo)-​4-​imidazolidineheptanoic acid
CAS Number 72814-32-5
Molecular Formula C19H32N2O5
Formula Weight 368.5
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(N1[H]​)​[C@H]​(CCCCCCC(O)​=O)​N(CCC(O)​C2CCCCC2)​C1=O

Background Reading

Narumiya, S., and Toda, N. Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. Br J Pharmacol 85 367-375 (1985).

Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270 18910-18916 (1995).

Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J Chem Soc Chem Commun 561-562 (1979).

Town, M., Casals-Stenzel, J., and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors. Prostaglandins 25 13-28 (1983).

Tokumoto, H., Watanabe, Y., Yamashita, A., et al. Specificity of prostaglandin D2 binding to synaptic membrane fraction of rat brain. Brain Res 362 114-121 (1986).

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BW 245C is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $52.00 $0.00
5 mg $234.00 $0.00
10 mg $416.00 $0.00
50 mg $1,820.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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BW 723C86
Prostaglandin D2

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