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BW 245C

Cayman Chemical Item Number 12050

(CAS 72814-32-5)

BW 245C (CAS 72814-32-5)

See more	Receptor Biochemistry (59) Prostaglandins (513)

Description

BW 245C is a selective agonist for the DP₁ receptor.^1,2 The K_i of BW 245C for the inhibition of [³H]-PGD₂ binding to isolated human platelet membranes is 0.9 nM.¹ It has a reported IC₅₀ of 2.5 nM for the inhibition of ADP-induced human platelet aggregation³ and an IC₅₀ of 250 nM for the inhibition of rat platelet aggregation.²

1 Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270 18910-18916 (1995).

2 Town, M., Casals-Stenzel, J., and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD₂ receptors. Prostaglandins 25 13-28 (1983).

3 Narumiya, S., and Toda, N. Different responsiveness of prostaglandin D₂-sensitive systems to prostaglandin D₂ and its analogues. Br J Pharmacol 85 367-375 (1985).

Formal Name	(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid
CAS Number	72814-32-5
Molecular Formula	C₁₉H₃₂N₂O₅
Formula Weight	368.5
Formulation	A crystalline solid
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(N1[H])[C@H](CCCCCCC(O)=O)N(CCC(O)C2CCCCC2)C1=O

Background Reading

Narumiya, S., and Toda, N. Different responsiveness of prostaglandin D₂-sensitive systems to prostaglandin D₂ and its analogues. Br J Pharmacol 85 367-375 (1985).

Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270 18910-18916 (1995).

Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J Chem Soc Chem Commun 561-562 (1979).

Town, M., Casals-Stenzel, J., and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD₂ receptors. Prostaglandins 25 13-28 (1983).

Tokumoto, H., Watanabe, Y., Yamashita, A., et al. Specificity of prostaglandin D₂ binding to synaptic membrane fraction of rat brain. Brain Res 362 114-121 (1986).

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BW 245C is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$52.00		$0.00
5 mg	$234.00		$0.00
10 mg	$416.00		$0.00
50 mg	$1,820.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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