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BW 246C

Cayman Chemical Item Number 12055

8-epi BW 245C (CAS 65705-83-1)

BW 246C (CAS 65705-83-1)

See more	Prostaglandins (517)

Description

BW 246C is the less active C-8 diastereomer of the DP receptor agonist BW 245C.^1,2 The activity of BW 245C is 70-fold greater than that of BW 246C.³

1 Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270 18910-18916 (1995).

2 Town, M., Casals-Stenzel, J., and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD₂ receptors. Prostaglandins 25 13-28 (1983).

3 Caldwell, A.G., Harris, C.J., Stepney, R., et al. Heterocyclic prostaglandin analogues. Part 2. Hydantoins and other imidazole analogues. J Chem Soc Perkin Trans I 495-505 (1980).

Synonyms	8-epi BW 245C
Formal Name	(4R)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid
CAS Number	65705-83-1
Molecular Formula	C₁₉H₃₂N₂O₅
Formula Weight	368.5
Formulation	A crystalline solid
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard [H]N(C(N(CCC(O)C1CCCCC1)[C@@H]2CCCCCCC(O)=O)=O)C2=O

Background Reading

Town, M., Casals-Stenzel, J., and Schillinger, E. Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD₂ receptors. Prostaglandins 25 13-28 (1983).

Caldwell, A.G., Harris, C.J., Stepney, R., et al. Heterocyclic prostaglandin analogues. Part 2. Hydantoins and other imidazole analogues. J Chem Soc Perkin Trans I 495-505 (1980).

Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270 18910-18916 (1995).

BW 246C is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$43.00		$0.00
5 mg	$194.00		$0.00
10 mg	$344.00		$0.00
50 mg	$1,505.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

BW 245C

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