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BW A868C

Cayman Chemical Item Number 12060

(CAS 118675-50-6)

BW A868C (CAS 118675-50-6)

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Description

BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C.1,2 BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells.3 It has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki for BW A868C is approximately 1.7 nM.4

1 Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J Chem Soc Chem Commun 561-562 (1979).

2 Trist, D.G., Collins, B.A., Wood, J., et al. The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. Br J Pharmacol 96 301-306 (1989).

3 Bhattacherjee, P., Jacobs, N., Coca-Prados, M., et al. Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Exp Eye Res 62 491-498 (1996).

4 Giles, H., Leff, P., Bolofo, M.L., et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br J Pharmacol 96 291-300 (1989).

Formal Name 3-​[(2-​cyclohexyl-​2-​hydroxyethyl)amino]-​2,​5-​dioxo-​1-​(phenylmethyl)-​4-​imidazolidineheptanoic acid
CAS Number 118675-50-6
Molecular Formula C25H37N3O5
Formula Weight 459.6
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1C(CCCCCCC(O)​=O)​N(NCC(O)​C2CCCCC2)​C(N1CC3=CC=CC=C3)​=O

Background Reading

Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J Chem Soc Chem Commun 561-562 (1979).

Bhattacherjee, P., Jacobs, N., Coca-Prados, M., et al. Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Exp Eye Res 62 491-498 (1996).

Trist, D.G., Collins, B.A., Wood, J., et al. The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. Br J Pharmacol 96 301-306 (1989).

Giles, H., Leff, P., Bolofo, M.L., et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br J Pharmacol 96 291-300 (1989).

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BW A868C is available in the following screening library:

Size Price Quantity Subtotal
1 mg $70.00 $0.00
5 mg $315.00 $0.00
10 mg $560.00 $0.00
50 mg $2,450.00 $0.00
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Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

BW 245C
BW 246C
Prostaglandin D2

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