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BW A868C

Cayman Chemical Item Number 12060

(CAS 118675-50-6)

BW A868C (CAS 118675-50-6)

See more	Receptor Biochemistry (59) Prostaglandins (513)

Description

BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C.^1,2 BW A868C antagonizes the prostaglandin D₂ and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells.³ It has virtually no effect on human TP, IP, EP₁, EP₂, and FP receptors. The K_i for BW A868C is approximately 1.7 nM.⁴

1 Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J Chem Soc Chem Commun 561-562 (1979).

2 Trist, D.G., Collins, B.A., Wood, J., et al. The antagonism by BW A868C of PGD₂ and BW245C activation of human platelet adenylate cyclase. Br J Pharmacol 96 301-306 (1989).

3 Bhattacherjee, P., Jacobs, N., Coca-Prados, M., et al. Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Exp Eye Res 62 491-498 (1996).

4 Giles, H., Leff, P., Bolofo, M.L., et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br J Pharmacol 96 291-300 (1989).

Formal Name	3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid
CAS Number	118675-50-6
Molecular Formula	C₂₅H₃₇N₃O₅
Formula Weight	459.6
Formulation	A solution in ethanol
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1C(CCCCCCC(O)=O)N(NCC(O)C2CCCCC2)C(N1CC3=CC=CC=C3)=O

Background Reading

Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J Chem Soc Chem Commun 561-562 (1979).

Bhattacherjee, P., Jacobs, N., Coca-Prados, M., et al. Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Exp Eye Res 62 491-498 (1996).

Trist, D.G., Collins, B.A., Wood, J., et al. The antagonism by BW A868C of PGD₂ and BW245C activation of human platelet adenylate cyclase. Br J Pharmacol 96 301-306 (1989).

Giles, H., Leff, P., Bolofo, M.L., et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br J Pharmacol 96 291-300 (1989).

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BW A868C is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$70.00		$0.00
5 mg	$315.00		$0.00
10 mg	$560.00		$0.00
50 mg	$2,450.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

BW 245C

BW 246C

Prostaglandin D₂

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