Cayman Chemical | 13,14-dihydro-15-keto Prostaglandin D2 | Description • 13,14-dihydro-15-keto PGD2 (CAS 59894-07-4)

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12610 13,14-dihydro-15-keto Prostaglandin D₂

13,14-dihydro-15-keto PGD₂ (CAS 59894-07-4)

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13,14-dihydro-15-keto Prostaglandin D₂ (13,14-dihydro-15-keto PGD₂) is a metabolite of PGD₂ which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD₂ was recently identified as a selective agonist for the CRTH₂/DP₂ receptor.¹ It also inhibits ion flux in a canine colonic mucosa preparation.² In humans, 13,14-dihydro-15-keto PGD₂ is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD₂ survives intact in the urine.^3,4

1 Rangachari, P.K., Betti, P. Biological activity of metabolites of PGD₂ on canine proximal colon. Am J Physiol 264, G886-G894 (1993).

2 Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D₂ selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH₂. J Exp Med 193(2) 255-261 (2001).

3 Liston, T.E., Roberts, L.J. Metabolic fate of radiolabeled prostaglandin D₂ in a normal human male volunteer. J Biol Chem 260 13172-13180 (1985).

4 Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D₂ by a stable isotope dilution mass spectrometric assay. Anal Biochem 193 142-148 (1991).

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