Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

13,14-dihydro-15-keto Prostaglandin D₂

Cayman Chemical Item Number 12610

13,14-dihydro-15-keto PGD₂ (CAS 59894-07-4)

13,14-dihydro-15-keto Prostaglandin D2 (CAS 59894-07-4)

See more	Prostaglandins (513)

Description

13,14-dihydro-15-keto Prostaglandin D₂ (13,14-dihydro-15-keto PGD₂) is a metabolite of PGD₂ which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD₂ was recently identified as a selective agonist for the CRTH2/DP₂ receptor.¹ It also inhibits ion flux in a canine colonic mucosa preparation.² In humans, 13,14-dihydro-15-keto PGD₂ is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD₂ survives intact in the urine.^3,4

1 Rangachari, P.K., and Betti, P. Biological activity of metabolites of PGD₂ on canine proximal colon. Am J Physiol 264 G886-G894 (1993).

2 Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D₂ selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 193(2) 255-261 (2001).

3 Liston, T.E., and Roberts, L.J. Metabolic fate of radiolabeled prostaglandin D₂ in a normal human male volunteer. J Biol Chem 260 13172-13180 (1985).

4 Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D₂ by a stable isotope dilution mass spectrometric assay. Anal Biochem 193 142-148 (1991).

Synonyms	13,14-dihydro-15-keto PGD2
Formal Name	9α-hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid
CAS Number	59894-07-4
Molecular Formula	C₂₀H₃₂O₅
Formula Weight	352.5
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(=O)CC[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O

Background Reading

Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D₂ by a stable isotope dilution mass spectrometric assay. Anal Biochem 193 142-148 (1991).

Rangachari, P.K., and Betti, P. Biological activity of metabolites of PGD₂ on canine proximal colon. Am J Physiol 264 G886-G894 (1993).

Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D₂ selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 193(2) 255-261 (2001).

Liston, T.E., and Roberts, L.J. Metabolic fate of radiolabeled prostaglandin D₂ in a normal human male volunteer. J Biol Chem 260 13172-13180 (1985).

Show all 4 Hide all but first 3

13,14-dihydro-15-keto Prostaglandin D2 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$100.00		$0.00
5 mg	$450.00		$0.00
10 mg	$800.00		$0.00
50 mg	$3,500.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

11-deoxy-11-methylene-15-keto Prostaglandin D₂

13,14-dihydro-15-keto Prostaglandin D₂-d₄

15-hydroxy Prostaglandin Dehydrogenase Polyclonal Antibody

Prostaglandin D₂

Prostaglandin Metabolite HPLC Mixture

Show all 5 Hide all but first 3

Downloads

	Download Product Insert 160 Kb PDF
	Download Material Safety Data Sheet (MSDS) 18 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

13,14-dihydro-15-keto Prostaglandin D2