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15-deoxy-Δ12,14-Prostaglandin D2

Cayman Chemical Item Number 12700

15-deoxy-Δ12,14-PGD2 (CAS 85235-11-6)

15-deoxy-Δ12,14-Prostaglandin D2 (CAS 85235-11-6)

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Description

15-deoxy-Δ12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-Δ12,14-PGJ2.1 It possesses cytotoxic effects on L1210 mouse leukemia cells in vitro with an IC50 of 0.3 µg/ml. 15-deoxy-Δ12,14-PGD2 is 10-fold more potent than PGD2 in this activity.2 However, it is a less effective inhibitor of ADP-induced platelet aggregation (IC50 = 320 ng/ml) compared to PGD2 (IC50 = 3 ng/ml).3

1 Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803-812 (1995).

2 Kato, T., Fukushima, M., Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Res 46 3538-3542 (1986).

3 Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem 26 790-799 (1983).

Synonyms
  • 15-deoxy-Δ12,14-PGD2
Formal Name 9α-​hydroxy-​11-​oxo-​prosta-​5Z,​12E,​14E-​trien-​1-​oic acid
CAS Number 85235-11-6
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in methyl acetate
Purity ≥95%
λmax 296 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1/C([C@@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(O)​C1)​=C/C=C/CCCCC

Background Reading

Kato, T., Fukushima, M., Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Res 46 3538-3542 (1986).

Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem 26 790-799 (1983).

Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. J Biol Chem 258 11713-11718 (1983).

Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803-812 (1995).

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15-deoxy-Δ12,14-Prostaglandin D2 is available in the following screening library:

Size Price Quantity Subtotal
500 µg $76.00 $0.00
1 mg $144.00 $0.00
5 mg $608.00 $0.00
10 mg $1,064.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

15-deoxy-Δ12,14-Prostaglandin J2
Prostaglandin D2

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