Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

tetranor-PGDM Exclusive

Cayman Chemical Item Number 12850

tetranor-PGD Metabolite

tetranor-PGDM

See more	Prostaglandins (513) Allergy/Asthma (97) Inflammation (383)

Description

Prostaglandin D₂ (PGD₂) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.¹ PGD₂ is also produced in the brain by lipocalin PGD-synthase also known as β-trace.^2,3 In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature.^2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.⁴ tetranor-PGDM is a major metabolite of PGD₂ that is detectable in human and mouse urine.⁵ The levels of tetranor-PGDM and 2,3-dinor-11β-PGF_2α, a related PGD₂ metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.⁵

1 Roberts, L.J., and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D₂ in a human female with mastocytosis. Prostaglandins 30 383-400 (1985).

2 Hayaishi, O. Sleep-wake regulation by prostaglandins D₂ and E₂. J Biol Chem 263 14593-14596 (1988).

3 Onoe, H., Ueno, R., Fujita, I., et al. Prostaglandin D₂, a cerebral sleep-inducing substance in monkeys. Proc Natl Acad Sci USA 85 4082-4086 (1988).

4 Giles, H., and Leff, P. The biology and pharmacology of PGD₂. Prostaglandins 35 277-300 (1988).

5 Song, W., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D₂ in mice and humans. J Biol Chem 283(2) 1179-1188 (2008).

Synonyms	tetranor-PGD Metabolite
Formal Name	9α-hydroxy-11,15-dioxo-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid
Molecular Formula	C₁₆H₂₄O₇
Formula Weight	328.4
Formulation	A solution in methyl acetate
Purity	≥90%
Stability	6 months
Storage	-80°C
Shipping	Dry ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(CCC(=O)O)CC[C@H]1C(=O)CC(O)C1CCC(=O)O

Background Reading

Song, W., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D₂ in mice and humans. J Biol Chem 283(2) 1179-1188 (2008).

Roberts, L.J., and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D₂ in a human female with mastocytosis. Prostaglandins 30 383-400 (1985).

Onoe, H., Ueno, R., Fujita, I., et al. Prostaglandin D₂, a cerebral sleep-inducing substance in monkeys. Proc Natl Acad Sci USA 85 4082-4086 (1988).

Giles, H., and Leff, P. The biology and pharmacology of PGD₂. Prostaglandins 35 277-300 (1988).

Hayaishi, O. Sleep-wake regulation by prostaglandins D₂ and E₂. J Biol Chem 263 14593-14596 (1988).

Show all 5 Hide all but first 3

Size	Price	Quantity	Subtotal
25 µg	$120.00		$0.00
50 µg	$228.00		$0.00
100 µg	$432.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

PGDM New

PGDM-d₄ New

Prostaglandin E₂

Prostaglandin E₂-d₉

tetranor-PGAM New Exclusive

tetranor-PGDM-d₆ Exclusive

tetranor-PGEM Exclusive

tetranor-PGEM-d₆ Exclusive

tetranor-PGFM Exclusive

tetranor-PGJM New Exclusive

Show all 10 Hide all but first 3

Downloads

	Download Product Insert 138 Kb PDF
	Download Material Safety Data Sheet (MSDS) 25 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640