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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin D3 Exclusive

Cayman Chemical Item Number 12990

PGD3 (CAS 71902-47-1)

Prostaglandin D3 (CAS 71902-47-1)

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Description

PGD3 is produced by the metabolism of EPA via the COX pathway.1 It is equipotent to PGD2 in decreasing systemic blood pressure in rats and in decreasing intraocular pressure in rabbits.2,3,4 However, it is 3-5 times more potent than PGD2 in the inhibition of ADP-induced human platelet aggregation.2

1 Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J Ocul Pharmacol 3 349-356 (1987).

2 Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem 26 790-799 (1983).

3 Goh, Y., Nakajima, M., Azuma, I., et al. Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits. Jpn J Ophthamol 32 471-480 (1988).

4 Kulkarni, P.S., and Srinivasan, B.D. Prostaglandins E3 and D3 lower intraocular pressure. Invest Ophthamol Vis Sci 26 1178-1182 (1985).

Synonyms
  • PGD3
Formal Name 9α,​15S-​dihydroxy-​11-​oxo-​prosta-​5Z,​13E,​17Z-​trien-​1-​oic acid
CAS Number 71902-47-1
Molecular Formula C20H30O5
Formula Weight 350.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@H]​(C1)​[C@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​C/C=C\CC)​C1=O

Background Reading

Goh, Y., Nakajima, M., Azuma, I., et al. Effects of prostaglandin D2 and its analogues on intraocular pressure in rabbits. Jpn J Ophthamol 32 471-480 (1988).

Kulkarni, P.S., and Srinivasan, B.D. Prostaglandins E3 and D3 lower intraocular pressure. Invest Ophthamol Vis Sci 26 1178-1182 (1985).

Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31 1159-1164 (1986).

Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem 26 790-799 (1983).

Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J Ocul Pharmacol 3 349-356 (1987).

Goh, Y., and Nakajima, M. Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions. Exp Eye Res 51 585-590 (1990).

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Prostaglandin D3 is available in the following screening library:

Size Price Quantity Subtotal
50 µg $71.00 $0.00
100 µg $135.00 $0.00
500 µg $568.00 $0.00
1 mg $994.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Eicosapentaenoic Acid
Prostaglandin D2

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