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Disuccinimidyl Suberate

Cayman Chemical Item Number 13008

DSS; NSC 340008 (CAS 68528-80-3)

Disuccinimidyl Suberate (CAS 68528-80-3)

See more	Protein Binding (33)

Description

Disuccinimidyl suberate (DSS) is a bifunctional cross-linking reagent which contains two N-hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-permeable and is commonly used to cross-link proteins in intact cells.^1,2

1 Hétu, P., Ouellet, M., Falgueyret, J., et al. Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E₂ synthase-1. Arch Biochem Biophys 477 155-162 (2008).

2 Ding, H., and Johnson, G.V.W. New application of b-galactosidase complementation to monitor tau self-association. J Neurochem 106 1545-1551 (2008).

Synonyms	DSS NSC 340008
Formal Name	1,8-bis(2,5-dioxo-1-pyrrolidinyl)ester octanedioic acid
CAS Number	68528-80-3
Molecular Formula	C₁₆H₂₀N₂O₈
Formula Weight	368.3
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O

Background Reading

Ding, H., and Johnson, G.V.W. New application of b-galactosidase complementation to monitor tau self-association. J Neurochem 106 1545-1551 (2008).

Hétu, P., Ouellet, M., Falgueyret, J., et al. Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E₂ synthase-1. Arch Biochem Biophys 477 155-162 (2008).

Size	Price	Quantity	Subtotal
50 mg	$7.00		$0.00
100 mg	$13.00		$0.00
250 mg	$32.00		$0.00
500 mg	$56.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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