Cayman Chemical | GSK264220A | Description (CAS 685506-42-7)

13009 GSK264220A

(CAS 685506-42-7)

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• See more Inhibitors; Vascular Disease

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Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as substrate. GSK264220A is a potent inhibitor of endothelial lipase (IC₅₀ = 16 nM).¹ Levels of HDL cholesterol are inversely correlated with endothelial lipase protein activity. Therefore, inhibition of endothelial lipase by compounds like GSK264220A may be expected to increase HDL levels and potentially decrease the risk of cardiovascular disease.

1 Keller, P.M., Rust, T., Murphy, D.J., et al. A high-throughput screen for endothelial lipase using HDL as substrate. Journal of Biomolecular Screening 13(6) 468-475 (2008).

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Pricing updated 2010-03-20.
Prices are subject to change without notice.

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