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GSK264220A

Cayman Chemical Item Number 13009

(CAS 685506-42-7)

GSK264220A (CAS 685506-42-7)

See more	Inhibitors (493) Vascular Disease (103)

Description

Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as substrate. GSK264220A is a potent inhibitor of endothelial lipase (IC₅₀ = 16 nM).¹ Levels of HDL cholesterol are inversely correlated with endothelial lipase protein activity. Therefore, inhibition of endothelial lipase by compounds like GSK264220A may be expected to increase HDL levels and potentially decrease the risk of cardiovascular disease.

1 Keller, P.M., Rust, T., Murphy, D.J., et al. A high-throughput screen for endothelial lipase using HDL as substrate. J Biomol Screen 13(6) 468-475 (2008).

Formal Name	N-[2-methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenyl-urea
CAS Number	685506-42-7
Molecular Formula	C₁₇H₂₁N₃O₄S
Formula Weight	363.4
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(Nc1ccccc1)Nc1cc(oc1C)S(=O)(=O)N1CCCCC1

Background Reading

Keller, P.M., Rust, T., Murphy, D.J., et al. A high-throughput screen for endothelial lipase using HDL as substrate. J Biomol Screen 13(6) 468-475 (2008).

GSK264220A is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$21.00		$0.00
5 mg	$95.00		$0.00
10 mg	$168.00		$0.00
25 mg	$368.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Endothelial Lipase Polyclonal Antibody

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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