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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin E1 Analytical Reference Standard

Cayman Chemical Item Number 13010.1

Alprostadil; PGE1 (CAS 745-65-3)

Prostaglandin E1 Analytical Reference Standard (CAS 745-65-3)

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Description

PGE1 analytical reference standard conforms to the quality specifications set by USP.1

1 . Alprostadil. 23rd ed. 48-49 (1995).

Synonyms
  • Alprostadil
  • PGE1
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 745-65-3
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation Light yellow to white needles
Purity >99%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1[C@H]​(CCCCCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1

Background Reading

Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

Feld, S., Li, G., Amirian, J., et al. Enhanced thrombolysis, reduced coronary reocclusion and limitation of infarct size with liposomal prostaglandin E1 in a canine thrombolysis model. J Am Coll Cardiol 24 1382-1390 (1994).

Olley, P.M., and Coceani, F. Prostaglandins and the ductus arteriosus. Annu Rev Med 32 375-3785 (1981).

Cawello, W., Schweer, H., Dietrich, B., et al. Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunction. J Urol 158 1403-1407 (1997).

Ramwell, P.W., Shaw, J.E., Corey, E.J., et al. Biological activity of synthetic prostaglandins. Nature 221 1251-1253 (1969).

Egashira, T., Kim, Y.I., Takayama, F., et al. Lipo-PGE1, prostaglandin E1 incorporated in lipid microspheres, protects injury of the liver caused by warm ischemia reperfusion. Free Radic Biol Med 21 353-356 (1996).

Padma-Nathan, H., Hellstrom, W.J.G., Kaiser, F.E., et al. Treatment of men with erectile dysfunction with transurethral alprostadil. N Engl J Med 336 1-7 (1997).

Antoine, C., Murphy, R.C., Henson, P.M., et al. Time-dependent utilization of platelet arachidonic acid by the neutrophil in formation of 5-lipoxygenase products in platelet-neutrophil co-incubations. Biochim Biophys Acta 1128 139-146 (1992).

Zoutendam, P.H., Bowman, P.B., Ryan, T.M., et al. Quantitative determination of alprostadil (PGE1) in bulk drug and pharmaceutical formulations by high-performance liquid chromatography. J Chromatogr 283 273-280 (1984).

Van Hijfte, L., and Kolb, M. Towards a large scale preparation of mexiprostil. Tetrahedron 48 6393-6402 (1992).

Wijkander, J., O'Flaherty, J.T., Nixon, A.B., et al. 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. J Biol Chem 270 26543-26549 (1995).

Miledi, R., and Woodward, R.M. Membrane currents elicited by prostaglandins, atrial natriuretic factor and oxytocin in follicle-enclosed Xenopus oocytes. J Physiol 416 623-643 (1989).

Okada, F., Nukada, T., Yamauchi, Y., et al. The hypotensive effect of prostaglandin E1 on hypertensive cases of various types. Prostaglandins 7 99-106 (1974).

Schweer, H., and Fischer, S. Negative ion chemical ionization and collisionally activated decomposition mass spectra of O-2,3,4,5,6-pentafluorobenzyloxime derivatives of prostaglandins. Biol Mass Spectrom 23 47-56 (1994).

Anderson, K., and Wagner, G. Physiology of penile errection. Physiol Rev 75 191-236 (1995).

Kobzar, G., Mardla, V., Järving, I., et al. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. Comp Biochem Physiol 106(2) 489-494 (1993).

Kim, E.D., and McVary, K.T. Topical prostaglandin-E1 for the treatment of erectile dysfunction. J Urol 153 1828-1830 (1995).

Bergström, S., and Samuelsson, B. Isolation of prostaglandin E1 from human seminal plasma. Prostaglandins and related factors 11. J Biol Chem 237 PC3005-PC3006 (1962).

Jacobs, H.A., Okano, T., and Kim, S.W. Antithrombogenic surfaces: Characterization and bioactivity of surface immobilized PGE1-heparin conjugate. J Biomed Mater Res 23 611-630 (1989).

Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc Est Acad Sci Chem 40 179-180 (1991).

. Alprostadil. 23rd ed. 48-49 (1995).

Earle, C.M., Keogh, E.J., Wisniewski, Z.S., et al. Prostaglandin E1 therapy for impotence, comparison with papaverine. J Urol 143 57-59 (1990).

Holcroft, J.W., Vassar, M.J., and Weber, C.J. Prostaglandin E1 and survival in patients with the adult respiratory distress syndrome. Ann Surg 203 371-378 (1986).

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Size Price Quantity Subtotal
1 mg $77.00 $0.00
5 mg $347.00 $0.00
10 mg $616.00 $0.00
50 mg $2,695.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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