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Prostaglandin E₁ Ethanolamide

Cayman Chemical Item Number 13012

PGE₁-EA; Alprostadil Ethanolamide (CAS 210976-81-1)

Prostaglandin E1 Ethanolamide (CAS 210976-81-1)

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Description

Prostaglandin E₁ ethanolamide (PGE₁-EA) is the ethanolamine-amide analog of PGE₁. Conversion of AEA, the ethanolamide of arachidonic acid, to PGE₂-EA has been demonstrated in vitro.^1,2 It is not established whether this conversion occurs in whole animals, nor has the pharmacology of the resultant prostaglandin ethanolamides been rigorously studied.

1 Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E₂ ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

2 Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

Synonyms	PGE1-EA Alprostadil Ethanolamide
Formal Name	N-(2-hydroxyethyl)-9-oxo-11α,15S-dihydroxy-prost-13E-en-1-amide
CAS Number	210976-81-1
Molecular Formula	C₂₂H₃₉NO₅
Formula Weight	397.6
Formulation	A crystalline solid
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)/C=C/[C@H]1C(O)CC(=O)C1CCCCCCC(=O)NCCO

Background Reading

Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E₂ ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

Prostaglandin E1 Ethanolamide is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$46.00		$0.00
5 mg	$207.00		$0.00
10 mg	$368.00		$0.00
50 mg	$1,610.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Prostaglandin E1 Ethanolamide