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Prostaglandin E1 Alcohol Exclusive

Cayman Chemical Item Number 13020

1-hydroxy Prostaglandin E1; PGE1 Alcohol (CAS 21562-57-2)

Prostaglandin E1 Alcohol (CAS 21562-57-2)

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Description

Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml.1,2 Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.1 PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.3

1 Nizankowska, E., Sheridan, A.Q., Maile, M.H., et al. Bronchodilatory properties of 2-decarboxy-2-hydroxymethyl prostaglandin E1. Prostaglandins 29 349-362 (1985).

2 Gardiner, P.J., Copas, J.L., Schneider, C., et al. 2-Decarboxy-2-hydroxymethyl prostaglandin E1 (TR4161), a prostaglandin bronchodilator of low tracheobronchial irritancy. Prostaglandins 19 349-370 (1980).

3 Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122 217-224 (1997).

Synonyms
  • 1-hydroxy Prostaglandin E1
  • PGE1 Alcohol
Formal Name 1,​11α,​15S-​trihydroxy-​prost-​13E-​en-​9-​one
CAS Number 21562-57-2
Molecular Formula C20H36O4
Formula Weight 340.5
Formulation White needles
Purity >99%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1[C@H]​(CCCCCCCO)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1

Background Reading

Nizankowska, E., Sheridan, A.Q., Maile, M.H., et al. Bronchodilatory properties of 2-decarboxy-2-hydroxymethyl prostaglandin E1. Prostaglandins 29 349-362 (1985).

Gardiner, P.J., Copas, J.L., Schneider, C., et al. 2-Decarboxy-2-hydroxymethyl prostaglandin E1 (TR4161), a prostaglandin bronchodilator of low tracheobronchial irritancy. Prostaglandins 19 349-370 (1980).

De Vries, G.W., Guarino, P., McLaughlin, A., et al. An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. Br J Pharmacol 115 1231-1234 (1995).

Prostaglandin E1 Alcohol is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $24.00 $0.00
1 mg $46.00 $0.00
5 mg $192.00 $0.00
10 mg $336.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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