See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin E1 Alcohol Exclusive

Cayman Chemical Item Number 13020

1-hydroxy Prostaglandin E1; PGE1 Alcohol (CAS 21562-57-2)

Prostaglandin E1 Alcohol (CAS 21562-57-2)

See more

Description

Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml.1,2 Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.1 PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.3

1 Nizankowska, E., Sheridan, A.Q., Maile, M.H., et al. Bronchodilatory properties of 2-decarboxy-2-hydroxymethyl prostaglandin E1. Prostaglandins 29 349-362 (1985).

2 Gardiner, P.J., Copas, J.L., Schneider, C., et al. 2-Decarboxy-2-hydroxymethyl prostaglandin E1 (TR4161), a prostaglandin bronchodilator of low tracheobronchial irritancy. Prostaglandins 19 349-370 (1980).

3 Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122 217-224 (1997).

Synonyms
  • 1-hydroxy Prostaglandin E1
  • PGE1 Alcohol
Formal Name 1,​11α,​15S-​trihydroxy-​prost-​13E-​en-​9-​one
CAS Number 21562-57-2
Molecular Formula C20H36O4
Formula Weight 340.5
Formulation White needles
Purity >99%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C1[C@H]​(CCCCCCCO)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1

Background Reading

Nizankowska, E., Sheridan, A.Q., Maile, M.H., et al. Bronchodilatory properties of 2-decarboxy-2-hydroxymethyl prostaglandin E1. Prostaglandins 29 349-362 (1985).

Gardiner, P.J., Copas, J.L., Schneider, C., et al. 2-Decarboxy-2-hydroxymethyl prostaglandin E1 (TR4161), a prostaglandin bronchodilator of low tracheobronchial irritancy. Prostaglandins 19 349-370 (1980).

De Vries, G.W., Guarino, P., McLaughlin, A., et al. An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. Br J Pharmacol 115 1231-1234 (1995).

Prostaglandin E1 Alcohol is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $24.00 $0.00
1 mg $46.00 $0.00
5 mg $192.00 $0.00
10 mg $336.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Prostaglandin E1
Prostaglandin E1 Analytical Reference Standard
Prostaglandin E1-d4

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?