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Valproic Acid (sodium salt)Cayman Chemical Item Number 13033
Sodium Valproate; 2- 
Valproic Acid (sodium salt) (CAS 1069-66-5)
Description
Valproic acid is an analog of the natural fatty acid valeric acid. The sodium salt of valproic acid has long been used as an anticonvulsant to prevent many kinds of seizures. It is an inhibitor of histone deacetylases (HDACs), inhibiting Class I HDACs with an IC50 of ~2 mM.1 Valproic acid also inhibits glycogen synthase kinase 3 (GSK3) and depletes cellular inositol-
1 Göttlicher, M., Minucci, S., Zhu, P., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20(24) 6969-6978 (2001).
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Williams, R.S.B., Cheng, L., Mudge, A.W., et al. A common mechanism of action for three mood- 3 Noguchi, H., Yamashita, H., Murakami, T., et al. Successful treatment of anaplastic thyroid carcinoma with a combination of oral valproic acid, chemotherapy, radiation and surgery. Endocr J 56(2) 245-249 (2009). 4 Qing, H., He, G., Ly, P.T.T., et al. Valproic acid inhibits Aβproduction, neuritic plaque formation, and behavioral deficits in Alzheimer’s disease mouse models. J Exp Med 205(12) 2781-2789 (2008).
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Bug, G., Gül, H., Schwarz, K., et al. Valproic acid stimulates proliferation and self-
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Jung, G., Yoon, J., Moon, B., et al. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-
Background ReadingJung, G., Yoon, J., Moon, B., et al. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta- Bug, G., Gül, H., Schwarz, K., et al. Valproic acid stimulates proliferation and self- Göttlicher, M., Minucci, S., Zhu, P., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20(24) 6969-6978 (2001). Williams, R.S.B., Cheng, L., Mudge, A.W., et al. A common mechanism of action for three mood- Qing, H., He, G., Ly, P.T.T., et al. Valproic acid inhibits Aβproduction, neuritic plaque formation, and behavioral deficits in Alzheimer’s disease mouse models. J Exp Med 205(12) 2781-2789 (2008). Show all 5 Hide all but first 3Valproic Acid (sodium salt) is available in the following screening libraries: |
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