13045 ATB-343
(CAS 1000700-26-4)
ATB-343 Workbook Links
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Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity.1 Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-343 is a hybrid molecule of an H2S donor and the NSAID indomethacin. In rats, ATB-343 does not cause gastric damage or promote leukocyte adherence to vascular endothelium, effects which are observed with indomethacin treatment alone.2 These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.
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1
Li, L., Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air?. Trends Pharmacol Sci 29(2) 84-90 (2007).
2
Wallace, J.L. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends Pharmacol Sci 28(10) 501-505 (2007).
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Pricing updated 2010-03-16.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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