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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

ATB-343 Exclusive

Cayman Chemical Item Number 13045

(CAS 1000700-26-4)

ATB-343 (CAS 1000700-26-4)

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Description

Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity.1 Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-343 is a hybrid molecule of an H2S donor and the NSAID indomethacin. In rats, ATB-343 does not cause gastric damage or promote leukocyte adherence to vascular endothelium, effects which are observed with indomethacin treatment alone.2 These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.

1 Li, L., and Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air? Trends Pharmacol Sci 29(2) 84-90 (2007).

2 Wallace, J.L. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends Pharmacol Sci 28(10) 501-505 (2007).

Formal Name 1-​(4-​chlorobenzoyl)-​5-​methoxy-​2-​methyl-​4-​(3-​thioxo-​3H-​1,​2-​dithiol-​5-​yl)phenyl ester-​1H-​indole-​3-​acetic acid
CAS Number 1000700-26-4
Molecular Formula C28H20ClNO4S3
Formula Weight 566.1
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc2c(c1)​c(CC(=O)​Oc1ccc(cc1)​c1ssc(=S)​c1)​c(C)​n2C(=O)​c1ccc(Cl)​cc1

Background Reading

Li, L., and Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air? Trends Pharmacol Sci 29(2) 84-90 (2007).

Wallace, J.L. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends Pharmacol Sci 28(10) 501-505 (2007).

ATB-343 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $28.00 $0.00
5 mg $126.00 $0.00
10 mg $224.00 $0.00
50 mg $980.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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