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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

1a,1b-dihomo Prostaglandin E1

Cayman Chemical Item Number 13050

1a,1b-dihomo PGE1

1a,1b-dihomo Prostaglandin E1

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Description

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.1,2 COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.3 In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.4

1 Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

2 Hoshi, K. Approved indications of lipo-PGE1 in Japan. Adv Drug Deliv Rev 20 171-176 (1996).

3 Samel, N., and Maxey, K.M. Personal Communication. (2003).

4 Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta 187 285-292 (1969).

Synonyms
  • 1a,1b-dihomo PGE1
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​1a,​1b-​dihomo-​prost-​13E-​en-​1-​oic acid
Molecular Formula C22H38O5
Formula Weight 382.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(=O)​C1CCCCCCCCC(=O)​O

Background Reading

Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

Samel, N., and Maxey, K.M. Personal Communication. (2003).

Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta 187 285-292 (1969).

Hoshi, K. Approved indications of lipo-PGE1 in Japan. Adv Drug Deliv Rev 20 171-176 (1996).

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1a,1b-dihomo Prostaglandin E1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
50 mg $1,610.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

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Prostaglandin A1 methyl ester Exclusive
Prostaglandin E1

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