Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…

Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Naphthofluorescein

Cayman Chemical Item Number 13055

CCG 8295 (CAS 61419-02-1)

Naphthofluorescein (CAS 61419-02-1)

See more	Inhibitors (546) Alzheimer's Research (48) Atherosclerosis (325) Cancer (666) Cell Biology (303) Infectious Disease (72)

Description

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC₅₀ = 12 μM).¹ It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase MT1-MMP, resulting in decreased levels of active MT1-MMP.¹ This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.¹ Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.¹ The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined

1 Coppola, J.M., Bhojani, M.S., Ross, B.D., et al. A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia 10(4) 363-370 (2008).

Synonyms	CCG 8295
Formal Name	3,11-dihydroxy-spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one
CAS Number	61419-02-1
Molecular Formula	C₂₈H₁₆O₅
Formula Weight	432.4
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard [Na].[Na].Oc1ccc2c(ccc3c2Oc2c4ccc(O)cc4ccc2C23OC(=O)c3ccccc23)c1

Background Reading

Coppola, J.M., Bhojani, M.S., Ross, B.D., et al. A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia 10(4) 363-370 (2008).

Size	Price	Quantity	Subtotal
1 mg	$22.00		$0.00
5 mg	$99.00		$0.00
10 mg	$176.00		$0.00
50 mg	$770.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

ARP 100

cis-ACCP

Downloads

	Download Product Insert 106 Kb PDF
	Download Material Safety Data Sheet (MSDS) 23 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640