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Naphthofluorescein

Cayman Chemical Item Number 13055

CCG 8295 (CAS 61419-02-1)

Naphthofluorescein (CAS 61419-02-1)

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Description

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC₅₀ = 12 μM).¹ It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase MT1-MMP, resulting in decreased levels of active MT1-MMP.¹ This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.¹ Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.¹ The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined

1 Coppola, J.M., Bhojani, M.S., Ross, B.D., et al. A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia 10(4) 363-370 (2008).

Synonyms	CCG 8295
Formal Name	3,11-dihydroxy-spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one
CAS Number	61419-02-1
Molecular Formula	C₂₈H₁₆O₅
Formula Weight	432.4
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard [Na].[Na].Oc1ccc2c(ccc3c2Oc2c4ccc(O)cc4ccc2C23OC(=O)c3ccccc23)c1

Background Reading

Coppola, J.M., Bhojani, M.S., Ross, B.D., et al. A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia 10(4) 363-370 (2008).

Size	Price	Quantity	Subtotal
1 mg	$22.00		$0.00
5 mg	$99.00		$0.00
10 mg	$176.00		$0.00
50 mg	$770.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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