Cayman Chemical | 17(R)-Resolvin D1 | Description • AT-RvD1; Aspirin-triggered-Resolvin D1; 17(R)-RvD1 (CAS 528583-91-7)

13060 17(R)-Resolvin D1

AT-RvD1; Aspirin-triggered-Resolvin D1; 17(R)-RvD1 (CAS 528583-91-7)

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• See more Lipoxins; Immunology; Inflammation

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Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA).¹ In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.² Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.¹ 17(R)-Resolvin D1 is an aspirin-triggered epimer of resolvin D1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to resolvin D1 (EC₅₀ ~30 nM).³ 17(R)-Resolvin D1 exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.³ In contrast to resolvin D1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases.

1 Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).

2 Ariel, A., Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4) 176-183 (2007).

3 Sun, Y., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem 282(13) 9323-9334 (2007).

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Pricing updated 2010-03-16.
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