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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

17(R)-Resolvin D1 Exclusive

Cayman Chemical Item Number 13060

AT-RvD1; Aspirin-triggered-Resolvin D1; 17(R)-RvD1 (CAS 528583-91-7)

17(R)-Resolvin D1 (CAS 528583-91-7)

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Description

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.1 17(R)-Resolvin D1 is an aspirin-triggered epimer of resolvin D1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to resolvin D1 (EC50 ~30 nM).3 17(R)-Resolvin D1 exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.3 In contrast to resolvin D1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases.

1 Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).

2 Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).

3 Sun, Y., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem 282(13) 9323-9334 (2007).

Synonyms
  • AT-RvD1
  • Aspirin-triggered-Resolvin D1
  • 17(R)-RvD1
Formal Name 7S,​8R,​17R-​trihydroxy-​4Z,​9E,​11E,​13Z,​15E19Z-​docosahexaenoic acid
CAS Number 528583-91-7
Molecular Formula C22H32O5
Formula Weight 376.5
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C[C@@H]​(O)​\C=C\C=C\C=C/C=C\[C@@H]​(O)​C(O)​C/C=C\CCC(=O)​O

Background Reading

Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).

Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).

Sun, Y., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem 282(13) 9323-9334 (2007).
Size Price Quantity Subtotal
10 µg $123.00 $0.00
25 µg $292.00 $0.00
50 µg $554.00 $0.00
100 µg $984.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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