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ApoAI Blocking Peptide

Cayman Chemical Item Number 13079

Apolipoprotein A-I; Apolipoprotein AI

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Description

ApoAI is a major protein component in high-density lipoproteins (HDLs). It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues and transports cholesterol to the liver and other tissues for excretion and steroidogenesis.1 Serum ApoAI levels are inversely related to the risk of developing atherosclerosis.2 Loss-of-function mutations are causes of diseases such as HDL deficiency type 1 (or Tangier disease) and type 2 (familial hypoalphalipoproteinemia), and systemic non-neuropathic amyloidosis.3,4 ApoAI is comprised of a single polypeptide chain of 243 amino acids residues with an estimated molecular weight of 28 kDa. Cayman’s ApoAI Polyclonal Antibody detects the protein by Western blot analysis in tissue/cell samples such as liver, intestine, and Hep-G2 cells.

1 Ajees, A.A., Anantharamaiah, G.M., Mishra, V.K., et al. Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases. Proc Natl Acad Sci USA 103(7) 2126-2131 (2006).

2 Haas, M.J., Reinacher, D., Li, J.P., et al. Regulation of apoA1 gene expression with acidosis: Requirement for a transcriptional repressor. J Mol Endocrinol 27 43-57 (2001).

3 Tall, A.R., and Wang, N. Tangier disease as a test of the reverse cholesterol transport hypothesis. J Clin Invest 106(10) 1205-1207 (2000).

4 Cheung, M.C., Mendez, A.J., Wolf, A.C., et al. Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling tangier disease and their effects on intracellular cholesterol efflux. J Clin Invest 91 522-529 (1993).

Synonyms
  • Apolipoprotein A-I
  • Apolipoprotein AI
Formulation 200 µg of peptide in 200 µl TBS, pH 7.2, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Haas, M.J., Reinacher, D., Li, J.P., et al. Regulation of apoA1 gene expression with acidosis: Requirement for a transcriptional repressor. J Mol Endocrinol 27 43-57 (2001).

Tall, A.R., and Wang, N. Tangier disease as a test of the reverse cholesterol transport hypothesis. J Clin Invest 106(10) 1205-1207 (2000).

Cheung, M.C., Mendez, A.J., Wolf, A.C., et al. Characterization of apolipoprotein A-I- and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling tangier disease and their effects on intracellular cholesterol efflux. J Clin Invest 91 522-529 (1993).

Ajees, A.A., Anantharamaiah, G.M., Mishra, V.K., et al. Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases. Proc Natl Acad Sci USA 103(7) 2126-2131 (2006).

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Size Price Quantity Subtotal
200 µg $107.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

ApoAI Polyclonal Antibody

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