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Resorcinolnaphthalein

Cayman Chemical Item Number 13082

NSC 354317 (CAS 41307-63-5)

Resorcinolnaphthalein (CAS 41307-63-5)

See more	Cardiology (79) Hypertension (90)

Description

Angiotensin-converting enzyme 2 (ACE2) is an enzyme that is cardioprotective and renoprotective. Resorcinolnaphthalein increases the activity of ACE2 in vitro (EC₅₀ = 19.5 μM).¹ Activation of ACE2 in rats produces a decrease in blood pressure and improvement in cardiac function. In spontaneously hypertensive rats it produces a reversal of myocardial, perivascular, and renal fibrosis.

1 Prada, J.A.H., Ferreira, A.J., Katovich, M.J., et al. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension 51 1312-1317 (2008).

Synonyms	NSC 354317
Formal Name	3',6'-dihydroxy-spiro[1H,3H-naphtho[1,8-cd]pyran-1,9'-[9H]xanthen-3-one
CAS Number	41307-63-5
Molecular Formula	C₂₄H₁₄O₅
Formula Weight	382.4
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard Oc1ccc2c(c1)Oc1cc(O)ccc1C12OC(=O)c2cccc3cccc1c23

Background Reading

Prada, J.A.H., Ferreira, A.J., Katovich, M.J., et al. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension 51 1312-1317 (2008).

Size	Price	Quantity	Subtotal
5 mg	$16.00		$0.00
10 mg	$30.00		$0.00
50 mg	$128.00		$0.00
100 mg	$224.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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