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Tenovin-1 Exclusive

Cayman Chemical Item Number 13085

(CAS 380315-80-0)

Tenovin-1 (CAS 380315-80-0)

See more	Inhibitors (493) Cancer (606) Cell Cycle (71) Epigenetics (175)

Description

Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.¹ Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD⁺-dependent class III histone deacetylases that belong to the sirtuin family.¹ While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.

1 Lain, S., Hollick, J.J., Campbell, J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454-463 (2008).

Formal Name	N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide
CAS Number	380315-80-0
Molecular Formula	C₂₀H₂₃N₃O₂S
Formula Weight	369.5
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC(=O)Nc1ccc(cc1)NC(=S)NC(=O)c1ccc(cc1)C(C)(C)C

Background Reading

Lain, S., Hollick, J.J., Campbell, J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454-463 (2008).

Tenovin-1 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
5 mg	$26.00		$0.00
10 mg	$49.00		$0.00
50 mg	$208.00		$0.00
100 mg	$364.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

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