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Tenovin-6

Cayman Chemical Item Number 13086

(CAS 1011557-82-6)

Tenovin-6 (CAS 1011557-82-6)

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Description

The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is a analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 expression in MCF-7 cells and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg.1 Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 µM, respectively.1

1 Lain, S., Hollick, J.J., Campbell, J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454-463 (2008).

Formal Name N-​[[[4-​[[5-​(dimethylamino)-​1-​oxopentyl]amino]phenyl]amino]thioxomethyl]-​4-​(1,​1-​dimethylethyl)-​benzamide
CAS Number 1011557-82-6
Molecular Formula C25H34N4O2S
Formula Weight 454.6
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​(C)​C1=CC=C(C(NC(NC2=CC=C(NC(CCCCN(C)​C)​=O)​C=C2)​=S)​=O)​C=C1

Background Reading

Lain, S., Hollick, J.J., Campbell, J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13 454-463 (2008).

Tenovin-6 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $131.00 $0.00
5 mg $590.00 $0.00
10 mg $1,048.00 $0.00
25 mg $2,293.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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