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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Δ17-Prostaglandin E1

Cayman Chemical Item Number 13090

5,6-dihydro PGE3; Δ17-PGE1 (CAS 7046-45-9)

Δ17-Prostaglandin E1 (CAS 7046-45-9)

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Description

Δ17-PGE1 is a naturally occurring E-series prostaglandin produced by the COX metabolism of ω-3 arachidonic acid. It was first isolated and characterized as a product of ram seminal vesicle microsomes.1 The relative abundance of Δ17-PGE1 in humans and other animals is low in comparison with PGE2, and is likely to be a reflection of precursor fatty acid abundance in the phospholipid PUFA reservoir. Definitive studies on the biosynthesis of Δ17-PGE1 in intact animals have not been done. Δ17-PGE1 is about half as potent as PGE1 as an inhibitor of ADP-induced aggregation of rabbit PRP.2 In human PRP, Δ17-PGE1 is a more potent antiplatelet agonist than PGE1, with an IC50 of about 30 nM.3 The vascular effects of Δ17-PGE1 have not been reported.

1 Samel, N., Järving, I., Lohmus, M., et al. Identification and biological activity of a novel natural prostaglandin, 5,6-dihydro-prostaglandin E3. Prostaglandins 33 137-146 (1987).

2 Kobzar, G., Mardla, V., Järving, I., et al. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. Comp Biochem Physiol 106(2) 489-494 (1993).

3 Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc Est Acad Sci Chem 40 179-180 (1991).

Synonyms
  • 5,6-dihydro PGE3
  • Δ17-PGE1
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​prosta-​13E,​17Z-​dien-​1-​oic acid
CAS Number 7046-45-9
Molecular Formula C20H32O5
Formula Weight 352.5
Formulation A crystalline solid
Purity >99%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC/C=C\CC(O)​/C=C/[C@H]​1C(O)​CC(=O)​C1CCCCCCC(=O)​O

Background Reading

Samel, N., Järving, I., Lohmus, M., et al. Identification and biological activity of a novel natural prostaglandin, 5,6-dihydro-prostaglandin E3. Prostaglandins 33 137-146 (1987).

Kobzar, G., Mardla, V., Järving, I., et al. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. Comp Biochem Physiol 106(2) 489-494 (1993).
Size Price Quantity Subtotal
1 mg $64.00 $0.00
5 mg $288.00 $0.00
10 mg $512.00 $0.00
50 mg $2,240.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Prostaglandin E1
Prostaglandin E3 Exclusive
ω-3 Arachidonic Acid

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