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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

13,14-dihydro-15-keto-tetranor Prostaglandin D2 Exclusive

Cayman Chemical Item Number 13100

13,14-dihydro-15-keto-tetranor Prostaglandin D2

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Description

A common metabolic pathway for several prostaglandins (PGs), including PGD2, involves the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the α-terminus and oxidation of the terminal ω-carbon produces the abundant urinary metabolites, including tetranor-PGDM.1 13,14-dihydro-15-keto-tetranor PGD2 is a potential metabolite of PGD2. It would be produced from the known metabolite 13,14-dihydro-15-keto PGD2 (Catalog No. 12610), which is a known agonist for the CRTH2/DP2 receptor.2

1 Song, W., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. J Biol Chem 283(2) 1179-1188 (2008).

2 Rangachari, P.K., and Betti, P. Biological activity of metabolites of PGD2 on canine proximal colon. Am J Physiol 264 G886-G894 (1993).

Formal Name 9α-​hydroxy-​11,​15-​dioxo-​2,​3,​4,​5-​tetranor-​prostanoic acid
Molecular Formula C16H26O5
Formula Weight 298.4
Formulation A solution in ethanol
Purity ≥95%
Stability 6 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(=O)​CC[C@H]​1C(=O)​CC(O)​C1CCC(=O)​O

Background Reading

Song, W., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. J Biol Chem 283(2) 1179-1188 (2008).

Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 193(2) 255-261 (2001).
Size Price Quantity Subtotal
10 µg $80.00 $0.00
25 µg $190.00 $0.00
50 µg $360.00 $0.00
100 µg $640.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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