Cayman Chemical | 13,14-dihydro-15-keto-tetranor Prostaglandin E2

13101 13,14-dihydro-15-keto-tetranor Prostaglandin E₂

(CAS 20675-85-8)

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• See more Prostaglandins; Inflammation

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A common metabolic pathway for several prostaglandins (PG), including PGE₂, involves the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the α-terminus and oxidation of the terminal ω-carbon produces the abundant urinary metabolites, including tetranor PGEM.¹ 13,14-dihydro-15-keto tetranor PGE₂ is a potential metabolite of PGE₂. It would be produced from the known metabolite 13,14-dihydro-15-keto PGE₂ (Catalog No. 14650), which is known to have a short plasma half-life.^2,3,4 13,14-dihydro-15-keto tetranor PGE₂ is a potential metabolite of PGE₂. It would be produced from the known metabolite 13,14-dihydro-15-keto PGE₂ (Catalog No. 14650), which is known to have a short plasma half-life.^2,3,4

1 Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Commun 49 720-726 (1972).

2 Bothwell, W., Verburg, M., Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E₁ and E₂: An indirect index of their in vivo disposition and pharmacokinetics. J Pharmacol Exp Ther 220 229-235 (1982).

3 Fitzpatrick, F.A., Aguirre, R., Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE₂. Prostaglandins 19 917-931 (1980).

4 Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE₂: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

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Pricing updated 2010-03-19.
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