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13,14-dihydro-15-keto-tetranor Prostaglandin E₂ Exclusive

Cayman Chemical Item Number 13101

(CAS 20675-85-8)

13,14-dihydro-15-keto-tetranor Prostaglandin E2 (CAS 20675-85-8)

See more	Prostaglandins (513) Inflammation (383)

Description

A common metabolic pathway for several prostaglandins (PG), including PGE₂, involves the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the α-terminus and oxidation of the terminal ω-carbon produces the abundant urinary metabolites, including tetranor PGEM.¹ 13,14-dihydro-15-keto tetranor PGE₂ is a potential metabolite of PGE₂. It would be produced from the known metabolite 13,14-dihydro-15-keto PGE₂ (Catalog No. 14650), which is known to have a short plasma half-life.^2,3,4 13,14-dihydro-15-keto tetranor PGE₂ is a potential metabolite of PGE₂. It would be produced from the known metabolite 13,14-dihydro-15-keto PGE₂ (Catalog No. 14650), which is known to have a short plasma half-life.^2,3,4

1 Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Commun 49 720-726 (1972).

2 Bothwell, W., Verburg, M., Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E₁ and E₂: An indirect index of their in vivo disposition and pharmacokinetics. J Pharmacol Exp Ther 220 229-235 (1982).

3 Fitzpatrick, F.A., Aguirre, R., Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE₂. Prostaglandins 19 917-931 (1980).

4 Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE₂: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

Formal Name	9,15-dioxo-11α-hydroxy-2,3,4,5-tetranor-prostanoic acid
CAS Number	20675-85-8
Molecular Formula	C₁₆H₂₆O₅
Formula Weight	298.4
Formulation	A solution in ethanol
Purity	≥95%
Stability	6 months
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(CC[C@H]([C@H]1CCC(O)=O)[C@H](O)CC1=O)=O

Background Reading

Bothwell, W., Verburg, M., Wynalda, M., et al. A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E₁ and E₂: An indirect index of their in vivo disposition and pharmacokinetics. J Pharmacol Exp Ther 220 229-235 (1982).

Fitzpatrick, F.A., Aguirre, R., Pike, J.E., et al. The stability of 13,14-dihydro-15 keto-PGE₂. Prostaglandins 19 917-931 (1980).

Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE₂: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Commun 49 720-726 (1972).

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Size	Price	Quantity	Subtotal
10 µg	$80.00		$0.00
25 µg	$190.00		$0.00
50 µg	$360.00		$0.00
100 µg	$640.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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13,14-dihydro-15-keto Prostaglandin E₂

tetranor-PGEM Exclusive

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13,14-dihydro-15-keto-tetranor Prostaglandin E2 Exclusive